Advancements in biomedical engineering: developing hydrogels for tissue regeneration and drug delivery

Hydrogels are a 3-D network of highly absorbent polymers that have been investigated since the late 20th century for various biomedical applications, including drug delivery, wound healing, and tissue engineering. Their highly absorbent nature gives them a flexibility similar to natural tissues and allows oxygen, nutrients, proteins, and other biomolecules to readily enter and nourish

Akron Joins Leading Companies and Research Institutions at the ARMI | BioFabUSA Spring Summit to Accelerate Innovation in Tissue Engineering

Akron Biotech recently participated in the ARMI | BioFabUSA Spring Summit in Manchester, NH, joining several leading research institutions and companies to continue charting a path forward for the tissue engineering industry. If we think about innovation as a process of bringing old ideas together to make new things, then ARMI is uniquely suited to

Tissue engineered spinal discs as a replacement for degenerated intervertebral discs

Spinal fusion surgery is often the answer to cases of severe intervertebral disc degeneration where the cushioning that sits between the spinal vertebrae becomes damaged, causing patients to experience back and neck pain. However, the surgery does not restore native structure or mechanical function. Degeneration of the intervertebral disc (IVD) is due to combination of

Engineered lungs successfully transplanted into pigs

A daunting challenge that faces tissue engineering is the requirement to generate perfused microvasculature networks capable of delivering nutrients to and removing waste from tissues. This engineered circulatory system is critical to supporting tissue survival. Vascularization is particularly important for the production of bioengineered lungs, which requires coordination of the circulatory and respiratory systems to

Vibrations replace media to induce differentiation of MSCs into bone tissue

Bone is the second most grafted tissue after blood – however, autologous grafts are in short supply and allogeneic grafts are associated with problems including rejection by the body and post-transplant complications. For that reason, much work has been put into optimizing existing and finding new ways for creating induced bone grafts through tissue engineering,

Fibronectin and BMP act in synergy to improve osteogenic activity

Fibronectin is well-known as an attachment extracellular matrix (ECM) protein that promotes activity, including differentiation, of a number of cell types. It has also been used in a number of tissue engineered constructs to enhance their function as well as cellular proliferation. As a workhorse ECM protein, fibronectin’s use is well-established in many tissue engineering

Dual component nanofiber/hydrogel scaffold supports therapeutic drug and gene delivery

One of the structurally more attractive features of nanofiber scaffolds is their three-dimensional architecture. Because they are thought to more closely mimic the size and environment of the natural extracellular matrix in the body, they continue to be studied not only as cell support scaffolds, but, a new study has shown, robust drug and gene delivery vehicles. Moreover,