New methods to improve cryopreservation for immunotherapies using a bioinspired solution

The preservation of biological samples is critical to the success of experimental studies and clinical treatments in the emergent field of immunotherapy. Cryopreservation – keeping cells at sub-zero temperatures – slows metabolic activity significantly, enabling storage and transportation, as well as a return to functionality upon thaw. Of course, it’s not as simple as placing

Baseline cytokine levels may predict the development of immune-mediated adverse events following immunotherapy

The development of immunotherapy is one of the greatest advances in cancer treatment, but up to 40% of cancer patients on immune checkpoint inhibitors develop clinically significant immune-related adverse events (irAEs) and up to 80% of individuals receiving checkpoint inhibitors experience some form of irAE. Predicting which patients will react negatively in response to immunotherapy

Therapeutic peptides anchored to enveloped viruses boost T cell immunotherapy

Cancer can exploit immune regulatory checkpoints molecules by inhibiting anti-tumor immune responses from T cells. These immune checkpoint inhibitor (ICI) antibodies that activate anti-tumor immune responses can create durable responses in 10%–20% of cancer patients, but the remaining 80%–90% of the patients do not respond, driving the need to find novel combination therapies that increase

Immunotherapy crosses blood-brain barrier to target glioblastoma

Chimeric antigen receptor T cell (CAR T) therapies have proved remarkably effective against leukemia and lymphoma, but for these therapies to target other types of cancer, there are still hurdles to overcome. Brain cancer is particularly challenging for immunotherapies due to the blood-brain barrier. This semi-permeable barrier tightly regulates the homeostasis of the central nervous

CAR NK cells may promise off-the-shelf immunotherapies with potent anti-tumor capabilities

Chimeric antigen receptors (CARs) significantly enhance the anti-tumor activity of immune effector cells. Current CAR-based immunotherapies leverage engineered versions of a patient’s own T-cells to target and kill cancer cells. Recently, a study led by researchers at University of California San Diego School of Medicine and University of Minnesota demonstrated that similarly modified CAR constructs

Presenting SUPRA CAR T cells – a split, universal, and programmable CAR system

T cells expressing chimeric antigen receptors (CAR T) are particularly promising for the treatment of refractory cancers. While Kymriah and Yescarta are FDA-approved for B-cell malignancies, safety and efficacy concerns remain across the cell therapy industry. Severe cytokine release syndrome triggered by T cell infusion is one of the urgent CAR T related downsides that needs

Innate Killer Summit 2018 presents cutting-edge innovations and the latest clinical data for NK cell therapies

Akron Biotech was proud to be a sponsor of this year’s Innate Killer Summit held in San Diego, California. The Innate Killer Summit is the leading, dedicated end-to-end meeting serving as a catalyst to ensure successful clinical and commercial translation of NK cell immunotherapies. The most current and advanced clinical data was presented as well