Advancements in biomedical engineering: developing hydrogels for tissue regeneration and drug delivery

Hydrogels are a 3-D network of highly absorbent polymers that have been investigated since the late 20th century for various biomedical applications, including drug delivery, wound healing, and tissue engineering. Their highly absorbent nature gives them a flexibility similar to natural tissues and allows oxygen, nutrients, proteins, and other biomolecules to readily enter and nourish

Slow release of immunotherapy after surgery prevents tumor recurrence and metastases

With the FDA approval of Kymriah to treat B-cell acute lymphoblastic leukemia and Yescarta to treat B-cell lymphoma, immunotherapy for cancer is becoming increasingly common. These existing therapies are systemically delivered and are not necessarily tumor-specific. This systemic administration can have major side effects by stimulating the activity of the entire immune system, not just

Wearable textile bandage releases wound-healing drugs on demand

Multiple approaches have been described for achieving therapeutically-effective wound healing. Biological factors that induce stimulation of cells to trigger and enhance the healing process have been extensively studied, and recently, new approaches for their delivery have been the focus of a vast number of studies. Delivery issues inherent to wound dressings include the need to

Dual component nanofiber/hydrogel scaffold supports therapeutic drug and gene delivery

One of the structurally more attractive features of nanofiber scaffolds is their three-dimensional architecture. Because they are thought to more closely mimic the size and environment of the natural extracellular matrix in the body, they continue to be studied not only as cell support scaffolds, but, a new study has shown, robust drug and gene delivery vehicles. Moreover,