Mitigating unintentional effects of pharmaceutical human serum albumin preparations in therapeutic cell culture

Human Serum Albumin (HSA) has historically been used in cell culture to support mammalian cell growth. Today’s advanced therapy companies regularly depend on HSA media supplementation to help expand targeted immunotherapeutic cell lines. Albumin is known to carry many important substances including lipids, amino acids, hormones, peptides, metals, and other undefined low molecular weight molecules.1