Mitigating unintentional effects of pharmaceutical human serum albumin preparations in therapeutic cell culture

Human Serum Albumin (HSA) has historically been used in cell culture to support mammalian cell growth. Today’s advanced therapy companies regularly depend on HSA media supplementation to help expand targeted immunotherapeutic cell lines. Albumin is known to carry many important substances including lipids, amino acids, hormones, peptides, metals, and other undefined low molecular weight molecules.1

Human-Derived Plasma Ancillary Materials for Cell Therapies: What Virus Inactivation Methods Should You Consider?

Human plasma is defined as “clear, straw colored, complex liquid that is 7% protein, 91% water, and 0.9% mineral salts” and can be derived from Source or Recovered Plasma. Today, human plasma is used to produce several ancillary materials such as Human AB Serum, Human Fibronectin, Human Serum Albumin (HSA), and Human Vitronectin. These materials