Electrospinning has become an attractive scaffold fabrication technique for tissue engineering and drug delivery. The format has highly tunable micro and nano architectural features and high surface area to volume ratio. The flexible manufacturing process can accommodate various synthetic and natural polymers tunable to specific degradation rates, drug release kinetics, mechanical properties, degrees of porosity, and diffusivity.
Bioengineered Scaffold Development and Fabrication
At Akron we design and produce electrospun scaffolds from various polymeric solutions rendering customer-specified deposition patterns including:
- Emulsion Electrospinning
- Co-axial Electrospinning
- Post-Electrospinning Surface Modification
- Sacrificial Fiber Electrospinning
- Scanning Electron Microscopy (SEM) imaging for fiber diameter/distribution, overall pore size/distribution, and patterning assessment.
- Atomic Force Microscopy (AFM) for physico-mechanical properties/topographical features
- UV-Vis Spectrophotometry/ELISA for release kinetics
- X-ray Photoelectron Spectroscopy (XPS) for degradation studies
- Fluorescence Microscopy for cellular assessment including Live/Dead cell assay, surface biomarkers, cell structures, etc.
- Surface modifications including Plasma Treatment
- Immobilization of Biologicals
- Electrospinning Expertise – Over a decade of experience with the electrospinning process and its variants, process development and improvement, performed on a plethora of synthetic and natural polymers with user-specified patterns.
- Small to Medium scale capacity – Capable of accommodating small batches for in-house testing as well as larger batches for clinical trial.
- cGMP – Availability of clean rooms for compliant products.