Recombinant Human Interleukin-1-beta, rHu IL-1ß
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Interleukin-1beta (IL-1ß) is a proinflammatory cytokine produced in response to inflammatory agents by a variety of cells, including monocytes, macrophages, and dendritic cells (DCs). IL-1ß and IL-1α are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1).
- Animal-Free protein
- Certificate of Analysis included with each order
- Lot-specific: SDS-PAGE, LAL analysis, and bioactivity
- Purity levels are 95% or greater
- Custom packaging for bulk orders
IL-1α and IL-1β have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock. Signaling activated by the IL-1R1 promotes these activities through a MYD88 signaling pathway similar to those associated with Toll receptors. Recombinant Human Interleukin-1-beta, produced in E.coli, is a non-glycosylated, polypeptide chain that contains 154 amino acids and has a molecular mass of 17.5 kDa. rHu IL-1ß is purified by proprietary chromotographic technique.
1 mg, 10 μg, 100 μg, 2 μg