cGMP Recombinant Human Insulin, rHu Insulin
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Serum-free medium supplements, such as insulin, are essential for long-term growth of commonly used mammalian cell lines. When insulin is absent from media, cells may exhibit disturbances in morphology and growth rate.
Features and Specifications:
- Custom packaging and sizes available
- Lyophilized format
- Pharmaceutical grade
- Custom biological activity assays available
Akron’s cGMP Cytokines are manufactured, tested and released in compliance with relevant cGMP guidelines. USP Chapter ‹1043› “Ancillary materials for cell, gene and tissue-engineered products” has been followed in the design of these products.
Recombinant human Insulin (rHu Insulin) is identical in function and structure to the native human sequence. A hormone consisting of two polypeptide chains, rHu Insulin′s A-chain (21 amino acids) and B-chain (30 amino acids) are covalently linked by disulfide bonds between cysteine residues. This genetically engineered human insulin is a full sequence molecule produced in baker’s yeast by recombinant DNA technology. rHu Insulin is a two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.