cGMP Recombinant Human Insulin, rHu Insulin

cGMP Recombinant Human Insulin, rHu Insulin

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Serum-free medium supplements, such as insulin, are essential for long-term growth of commonly used mammalian cell lines. When insulin is absent from media, cells may exhibit disturbances in morphology and growth rate.

Features and Specifications:

  • Custom packaging and sizes available
  • Lyophilized format
  • Pharmaceutical grade
  • Sterile-filled
  • Custom biological activity assays available

 

Quality Statement

Akron’s cGMP Cytokines are manufactured, tested and released in compliance with relevant cGMP guidelines. USP Chapter ‹1043› “Ancillary materials for cell, gene and tissue-engineered products” has been followed in the design of these products.


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Recombinant human Insulin (rHu Insulin) is identical in function and structure to the native human sequence. A hormone consisting of two polypeptide chains, rHu Insulin′s A-chain (21 amino acids) and B-chain (30 amino acids) are covalently linked by disulfide bonds between cysteine residues. This genetically engineered human insulin is a full sequence molecule produced in baker’s yeast by recombinant DNA technology. rHu Insulin is a two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.