cGMP Recombinant Human Interleukin-2, rHu IL-2
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Akron’s industry-leading IL-2 is produced under stringent cGMP guidelines in a variety of ready-to-use configurations.
Interleukin-2 promotes the growth and activity of T and B lymphocytes, and is key in a number of cell and cell-based gene therapies.
Features and Specifications:
- Available as 10µg, 100µg, and 1mg
- Source: E. Coli
- Identical amino acid sequence to aldesleukin (Proleukin®)
- Animal component free
- Defined functionally based on biological assays
- Sterile lyophilized and filled
- Sterility & endotoxin-tested according to USP
- 24 months stability
- Storage: 2-8°C
- Custom biologic activity assay available upon request
- DMF (eCTD format) Available
To request availability, pricing, or a letter of authorization for your fillings, please contact email@example.com.
Akron’s cGMP Cytokines are manufactured, tested and released in compliance with relevant cGMP guidelines. USP Chapter ‹1043› “Ancillary materials for cell, gene and tissue-engineered products” has been followed in the design of these products.
IL-2 signals through the IL-2R receptor in order to induce the proliferation of activated T cells. IL-2 also stimulates proliferation and differentiation of B cells, natural killer cells, monocytes and macrophages. Recombinant human IL-2 produced in E. coli is a non-glycosylated protein with a molecular weight of approximately 15.3 kDa. The recombinant sequence differs from native interleukin-2 in the following ways: a) the molecule has no N-terminal alanine; and b) the molecule has serine substituted for cysteine at amino acid position 125.