cGMP Recombinant Human Interleukin-2, rHu IL-2
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Interleukin-2 (IL-2) is an immuno-modulatory cytokine produced by stimulated T-cells. Akron’s industry-leading IL-2 is produced under stringent cGMP guidelines in a variety of ready-to-use configurations.
Features and Specifications:
- Custom packaging and sizes available
- Single-use syringe configuration
- Lyophilized or liquid format
- Pharmaceutical grade
- Custom biological activity assays available
- Drug Master File available (# 030268)
Akron’s cGMP Cytokines are manufactured, tested and released in compliance with relevant cGMP guidelines. USP Chapter ‹1043› “Ancillary materials for cell, gene and tissue-engineered products” has been followed in the design of these products.
IL-2 signals through the IL-2R receptor in order to induce the proliferation of activated T cells. IL-2 also stimulates proliferation and differentiation of B cells, natural killer cells, monocytes and macrophages. Recombinant human IL-2 produced in E. coli is a non-glycosylated protein with a molecular weight of approximately 15.3 kDa. The recombinant sequence differs from native interleukin-2 in the following ways: a) the molecule has no N-terminal alanine; and b) the molecule has serine substituted for cysteine at amino acid position 125.
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