cGMP Human Fibronectin, Viral-inactivated

cGMP Human Fibronectin, Viral-inactivated

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Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis.1

Features:

  • Concentration: 1 mg/mL
  • Origin: Human plasma from U.S. donors
  • The plasma units used in the manufacture of this product have been virus inactivated using a method validated for the inactivation of enveloped viruses.
  • Plasma units were collected in USFDA-registered facilities and were viral tested as per 21 CFR 610.40 at the time of collection.
  • cGMP product includes mycoplasma, endotoxin, and sterility testing
  • For research use or further manufacturing use in ex vivo cell therapy applications. cGMP grade blood derived products are not intended for direct in vivo use or for direct clinical use as a drug, therapeutic, biologic or medical device.
  • Custom packaging available for contract orders

Reference:

  1. Cai X, Liu C, Zhang TN, Zhu YW, Dong X, Xue P. Down-regulation of FN1 inhibits colorectal carcinogenesis by suppressing proliferation, migration, and invasion. J Cell Biochem. 2018 Jun;119(6):4717-4728.

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Fibronectin is an attachment factor that facilitates the attachment and cytoplasmic spreading of all types of anchorage-dependent cells.

Plasma-Derived Fibronectin

Plasma fibronectin (pFN) is secreted by hepatocytes as a major protein component of blood. pFN opsonizes bacteria and helps form clots. Plasma FN is widely used in cell culture to help cells attach to the substrate. It is particularly useful for culturing cells that are incapable of synthesizing their own biomatrix, including stem cells, and for culturing cells in serum-free medium. Akron’s pFN is a sterile, buffered solution with a pH from 7.0 to 8.0.