cGMP Recombinant Human Granulocyte-Colony Stimulating Factor, rHu G-CSF

cGMP Recombinant Human Granulocyte-Colony Stimulating Factor, rHu G-CSF

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Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptors expressed on the surface of hematopoietic stem cells. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell line.

Features and Specifications:

  • Custom packaging and sizes available
  • Single-use syringe configuration
  • Lyophilized or liquid format
  • Pharmaceutical grade
  • Sterile-filled
  • Custom biological activity assays available

 

Quality Statement

Akron’s cGMP Cytokines are manufactured, tested and released in compliance with relevant cGMP guidelines. USP Chapter ‹1043› “Ancillary materials for cell, gene and tissue-engineered products” has been followed in the design of these products.


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Granulocyte-Colony Stimulating Factor induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. The synthesis of G-CSF can be induced by bacterial endotoxins, TNFalpha, Interleukin-1 and GM-CSF. Prostaglandin E2 inhibits the synthesis of G-CSF. In epithelial, endothelial, and fibroblastic cells, secretion of G-CSF is induced by Interleukin-17. rHu G-CSF produced in E. coli is a single, non-glycosylated, polypeptide chain that contains 175 amino acids and has a molecular mass of 18.8 KD.