cGMP Recombinant Human Granulocyte-Colony Stimulating Factor, rHu G-CSF
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Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptors expressed on the surface of hematopoietic stem cells. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell line.
Features and Specifications:
- Custom packaging and sizes available
- Single-use syringe configuration
- Lyophilized or liquid format
- Pharmaceutical grade
- Custom biological activity assays available
Akron’s cGMP Cytokines are manufactured, tested and released in compliance with relevant cGMP guidelines. USP Chapter ‹1043› “Ancillary materials for cell, gene and tissue-engineered products” has been followed in the design of these products.
Granulocyte-Colony Stimulating Factor induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. The synthesis of G-CSF can be induced by bacterial endotoxins, TNFalpha, Interleukin-1 and GM-CSF. Prostaglandin E2 inhibits the synthesis of G-CSF. In epithelial, endothelial, and fibroblastic cells, secretion of G-CSF is induced by Interleukin-17. rHu G-CSF produced in E. coli is a single, non-glycosylated, polypeptide chain that contains 175 amino acids and has a molecular mass of 18.8 KD.