A new 3D bio-printing method shows great potential for tissue engineering scaffolds

Electrospinning has been an attractive scaffold fabrication technique for over a decade capable of introducing micro-architectural ques to enhance tissue engineering modalities. Nonetheless, only a handful or architecturally relevant structures can be accomplished with this technique which require complex set-ups in order to be rendered properly. On the other hand, 3D Bio-Printing has emerged as

The immune system’s fountain of youth clears old cells in mice to slow aging

Aging is characterized by a functional decline in many physiological systems. Cellular senescence, a central component of aging, is a cell-intrinsic stress response programmed to impose stable cell-cycle arrest in damaged cells. These senescent cells are not completely dead but do suffer loss of function or irreparable damage, and they have been implicated in diseases

Microneedle patch delivers cardiac stem cells to promote heart repair following heart attack

Myocardial infarctions, commonly called heart attacks, affect thousands of people every year. Myocardial infarctions occur when a blockage in the arteries causes a decrease in blood flow to the heart. This leads to irreversible damage to the heart muscles, loss of cardiac cells, and scarring. Cell therapy seeks to regenerate lost cardiac cells with cardiac

Tissue engineered spinal discs as a replacement for degenerated intervertebral discs

Spinal fusion surgery is often the answer to cases of severe intervertebral disc degeneration where the cushioning that sits between the spinal vertebrae becomes damaged, causing patients to experience back and neck pain. However, the surgery does not restore native structure or mechanical function. Degeneration of the intervertebral disc (IVD) is due to combination of

The unique metabolic properties of leukemia stem cells are proving to be their Achilles’ heel

Acute myeloid leukemia (AML) is characterized by an expansion of abnormal undifferentiated myeloblast due to an acquired mutation in blood-forming cells from the bone marrow, resulting in impaired hematopoiesis. The typical treatment for AML is induction chemotherapy but refractory disease is common, and relapse can occur causing initial and subsequent treatments to fail. This is

Baseline cytokine levels may predict the development of immune-mediated adverse events following immunotherapy

The development of immunotherapy is one of the greatest advances in cancer treatment, but up to 40% of cancer patients on immune checkpoint inhibitors develop clinically significant immune-related adverse events (irAEs) and up to 80% of individuals receiving checkpoint inhibitors experience some form of irAE. Predicting which patients will react negatively in response to immunotherapy

Oxygen inhibition controls rigidity of 3D bioprinted material to mimic heterogenous tissue environments

Tissue engineering has made extensive advances in the creation of biomaterials and scaffolds to better study the effects of treatments and therapies in vitro, but the spatial control over mechanical heterogeneity is a characteristic that scientists have struggled to achieve. The emergent rise of 3D printing has led to greater interest in 3D bioprinting through

Therapeutic peptides anchored to enveloped viruses boost T cell immunotherapy

Cancer can exploit immune regulatory checkpoints molecules by inhibiting anti-tumor immune responses from T cells. These immune checkpoint inhibitor (ICI) antibodies that activate anti-tumor immune responses can create durable responses in 10%–20% of cancer patients, but the remaining 80%–90% of the patients do not respond, driving the need to find novel combination therapies that increase