In the current issue of Nature, a group of scientists from the UK described results from comprehensive genotyping and phenotyping analysis of 522 open access human iPSCs derived from 189 healthy male and female individuals, as a means to characterize these cell lines for their use in research. The manuscript, titled Common genetic variation drives molecular heterogeneity in human iPSCs, is available here.
The effort is part of The Human Induced Pluripotent Stem Cell Initiative (HipSci), and the authors are from research and academic institutions that are part of the consortium: the European Molecular Biology Labroatory, the Wellcome Trust Sanger Institute, King’s College London, the European Bioinformatics Institute, the University of Dundee and the University of Cambridge.
The Human Induced Pluripotent Stem Cell Initiative (HipSci) was established in 2012 with the aim of addressing the need for a large, well-characterized collection of human-induced pluripotent stem cells (iPSCs) for use in research.
The cell lines generated originated from skin biopsides donated by healthy volunteers, which the scientists used to generate detailed genotype and phenotype data from, alongside identifying the cell biology of each cell line. Lines and data generated by this initiative are available to academic researchers and industry.
Next month, the Centre for Stem Cells & Regenerative Medicine in London is hosting a symposium of talks by researchers from the HipSci project. Set to take place on July 5th, 2017, the symposium will features talks from Dr. Fiona Watts, Dr. Dan Gaffney and other members of the HipSci project. More information can be found here.
To learn about the HipSci project, check out their official website.